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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Prostaglandin inhibits UCHL1. 2 / 2

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"Sequestosome 1/p62 and ubiquitin C-terminal hydrolase L1 (UCH-L1), which is inhibited by some of the prostaglandins of the J2 series, were co-localized in the protein aggregates containing ubiquitinat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Moreover, J2 prostaglandins inhibit the de-ubiquitinating enzyme UCH-L1 (Li et al., xref ; Liu et al., xref ), which is down-regulated in AD brains; UCH-L1 down-regulation is inversely proportional to the number of neurofibrillary tangles (Choi et al., xref )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...