IndraLab

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E2 increases the amount of KCNQ5. 8 / 8
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"As found in NPY neurons, E2 replacement significantly increased the mRNA expression of KCNQ5 in RNA extracted from the arcuate nucleus dissected from wild-type females but failed to alter KCNQ5 expression in ERalpha KO females (XREF_FIG)."
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"Because E2 regulates KCNQ5 and NPY gene expression in the arcuate but fails to increase KCNQ5 expression in NPY neurons in ERalpha KO mice, we determined the expression of ERalpha and ERbeta in single and pooled NPY neurons collected from ovariectomized females."
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"We have previously shown that E2 will increase KCNQ5 expression in the guinea pig arcuate nucleus both after 24 hr and long-term treatment using unbiased microarray analysis followed by quantitative real-time PCR."
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"E2 treatment increases the mRNA expression of the KCNQ5 channel subunit that underlies the M-current and the inwardly rectifying K + (Kir) channel Kir2.4 subunit."
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"Previously, we have shown that E2 (24 hr and long-term) increases the expression of KCNQ5 in guinea pig arcuate nucleus."
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"In the mouse, E2 replacement also increased the expression of KCNQ5 both in the whole arcuate and specifically in NPY neurons."
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"Because E2 increased the expression of KCNQ5 in NPY neurons, we wanted to determine if this was dependent on ERalpha."
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"E2 treatment increased the expression of the KCNQ5 subunit in females but not KCNQ2 or KCNQ3 subunits."
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