IndraLab

Statements

TNFAIP3 activates inflammatory response. 11 / 11
| 4 7
reach
"These findings show that neutrophilic airway inflammation induced by activated TNFAIP3 and A20 deficient myeloid cells can develop in the absence of IL-17RA-signalling."
30171721
eidos
"353 [ 4 ] Hsu ACY , Dua K , Starkey MR , Haw TJ , Nair PM , Nichol K , et al. MicroRNA-125a 354 and - b inhibit A20 and MAVS to promote inflammation and impair antiviral response 355 in COPD ."
| PMC
reach
"These are likely induced by TNFAIP3‐deficient cDC1s in the lungs; however, we cannot exclude that the IFNγ‐expressing T cells in the lung were partly induced by TNFAIP3‐deficient Langerhans cells in the skin, because skin DCs have been reported to mediate inflammation in the airways through the skin‐lung axis."
32329078
eidos
"3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3 , thereby blocking NF-kappaB pathway activation ."
32771556
reach
"Despite this interferon response, it was shown by the authors of the study [16], that the SARS-COV-2 virus is a low inducer of the IFN-I and IFN-III systems, a failure which likely contributes to the development of COVID-19 during the viral infection.A third module (c) revolves around TNF and includes IL1A, IL1B, TNFSF14, TNFAIP3, and CSF2 that likely mediates the inflammatory response associated with COVID-19 progression."
35085325
eidos
"Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson 's disease via the NFkappaB and mTOR pathways ."
37019273
reach
"Taken together, decreased expression of TNFAIP3 and its partners contribute to inflammation and up-regulation of apoptosis inhibitors that may create microenvironment for colorectal cancer."
28842689
reach
"Hepatocyte specific ablation of Tnfaip3 exacerbated nonalcoholic fatty liver disease- and NASH related phenotypes in mice, including glucose metabolism disorders, lipid accumulation and enhanced inflammation, in an ASK1 dependent manner."
29227477
eidos
"According with this view , we can assume that the A20 upregulation observed in sciatic nerve of 4 months old SOD1-G93A mice can be ascribed to an activation of the non-canonical pathway , fitting with the idea that A20 ( 62 ) , when aberrantly activated , in different cell types , can promote autoimmunity and inflammation ."
33329541
reach
"Cluster 2 contained IL8, IL1A, PTGS2, DTR, TNFAIP3, and CXCL3 that were up-regulated and linked primarily to inflammatory response and cell proliferation."
16330358
reach
"Tnfaip3 -/- Myd88 -/- double-mutant mice are rescued from lethal inflammation, suggesting that TLR signals drive the spontaneous inflammation in the absence of A20 [XREF_BIBR]."
21119682