IndraLab

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TNFAIP3 activates inflammatory response. 22 / 22
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"Compared with Tnfaip3 wild type (Tnfaip3 ) controls, a lung epithelium Tnfaip3 - knockout (Tnfaip3 ) mouse model produced less granulocyte-macrophage colony-stimulating factor and less eosinophil inflammation and Th2 response after house dust mites (HDMs) stimulation (16)."
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"After experiments and analysis, the conclusion of this study demonstrated that TNFAIP3 stimulated inflammatory response, apoptosis, and oxidative stress in vivo and in vitro by activating RIP3/NLRP3 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"According with this view , we can assume that the A20 upregulation observed in sciatic nerve of 4 months old SOD1-G93A mice can be ascribed to an activation of the non-canonical pathway , fitting with the idea that A20 ( 62 ) , when aberrantly activated , in different cell types , can promote autoimmunity and inflammation ."
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"The use of TNFAIP3 siRNA further increased inflammatory mediators and reduced permeability proteins, suggesting that increasing TNFAIP3 levels may reduce retinal inflammation."
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"Studies have shown that TNFAIP3 is a central modulator of cellular immunity and inflammation."
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"In the EAE model, miR-873 induced by IL-17 stimulation aggravated disease severity and increased inflammation by targeting Tumor Necrosis Factor Alpha-Induced Protein 3, or TNFAIP3 (A20)/NF-κ [123]."
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"Such GR/NF-κB interactions ensure that inflammation-induced feedback control of NF-κB by TNFAIP3 is maintained, or even enhanced, in the presence of glucocorticoid (14)."
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"These findings show that neutrophilic airway inflammation induced by activated TNFAIP3 and A20 deficient myeloid cells can develop in the absence of IL-17RA-signalling."
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"These are likely induced by TNFAIP3‐deficient cDC1s in the lungs; however, we cannot exclude that the IFNγ‐expressing T cells in the lung were partly induced by TNFAIP3‐deficient Langerhans cells in the skin, because skin DCs have been reported to mediate inflammation in the airways through the skin‐lung axis."
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"Calcium can activate DREAM, a Ca sensor protein that acts as a transcriptional repressor of A20/TNFAIP3, which negatively regulates the NF-κB activity to resolve inflammation."
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"Together, these results indicate that Tnfaip3-deficient hyperactivated basophils can exacerbate mild HDM-induced allergic airway inflammation, which is in part mediated by enhanced IL-33 responsiveness in this model."
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"Hepatocyte specific ablation of Tnfaip3 exacerbated nonalcoholic fatty liver disease- and NASH related phenotypes in mice, including glucose metabolism disorders, lipid accumulation and enhanced inflammation, in an ASK1 dependent manner."
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"TNFAIP3 overexpression could also lead to severe tissue damage and inflammation ."
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"Taken together, decreased expression of TNFAIP3 and its partners contribute to inflammation and up-regulation of apoptosis inhibitors that may create microenvironment for colorectal cancer."
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"Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson 's disease via the NFkappaB and mTOR pathways ."
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"The release of NFKB2, TRAF1, NFKBIA, IL8, and TNFAIP3, as important regulatory genes of NF-κB, can activate the upstream pathway NF-κB. Jayashankar et al. found that the intervention of supercritical carbon dioxide extract from seabuckthorn leaves can inhibit the expression levels of TNF-α and IL-6 after LPS-induced inflammatory damage, inhibit the activation of the MAPK/NF-κB signaling pathway, reduce inflammation, and play a immunomodulatory role (45)."
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"3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3 , thereby blocking NF-kappaB pathway activation ."
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"Tnfaip3 -/- Myd88 -/- double-mutant mice are rescued from lethal inflammation, suggesting that TLR signals drive the spontaneous inflammation in the absence of A20 [XREF_BIBR]."
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"Cluster 2 contained IL8, IL1A, PTGS2, DTR, TNFAIP3, and CXCL3 that were up-regulated and linked primarily to inflammatory response and cell proliferation."
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"The Tnfaip3 allele drives a sub-clinical, low-grade inflammation in the colon, liver and kidneys under SPF conditions, however these mice do not spontaneously develop overt autoimmune or inflammatory disease, (13)."
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"Targeted deletion of Tnfaip3 in cDC1s using a Tnfaip3-floxed allele combined with Langerin(Lg)-cre (referred to as Tnfaip3 mice ) was shown to abolish eosinophilic airway inflammation upon HDM sensitization, whereby lung cDC1s upregulated IL-12 production and Tc cells showed increased IFNγ production ."
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"Genetic ablation of Tnfaip3 in mice model causes multiorgan inflammation, cachexia, and perinatal mortality ."
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