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USP7 increases the amount of F_actin. 3 / 3
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"Additionally, reconstitution of USP7 +/- cells with USP7 Y143X found in subject # 6 failed to rescue CI-M6PR recycling or rescue Arp2/3 and F-actin levels on FAM21 positive endosomes (XREF_FIG)."
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"Furthermore, CRISPR and Cas9 knockout of USP7 in hypothalamic neurons resulted in similar phenotypes, including reduced TRIM27 protein levels and diminished the level of F-actin on FAM21 positive endo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, CRISPR and Cas9 knockout of USP7 in hypothalamic neurons resulted in similar phenotypes, including reduced TRIM27 protein levels (XREF_FIG) and diminished the level of F-actin on FAM21 positive endosomes (XREF_FIG)."
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