IndraLab

Statements

AGT activates KCNH2. 3 / 3
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"The protein kinase C (PKC) inhibitor bisindolylmaleimide 1 (1muM) antagonized the reduction of mature hERG channel protein induced by Ang II."
25218469
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"Pre-exposure of cardiomyocytes to a SUMOylation chemical inhibitor, ginkgolic acid, or the silencing of UBC9 suppressed PML SUMOylation, subsequently preventing the downregulation of HERG induced by ATO or Ang II."
28525371
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"Conversely, knockdown of RNF4 led to a remarkable increase in PML SUMOylation and the function of PML-NBs, further promoting ATO- or Ang II induced HERG protein downregulation."
28525371