IndraLab

Statements

USP18 activates SGCG. 3 / 3
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"CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV‐1 infection in macrophages.It is well established that type I IFNs (T1 IFNs) can restrict acute HIV‐1 infection in vitro.1, 2, 3, 4, 5 In clinical trials treating human patients with recombinant IFN‐α2a, T1 IFNs can suppress viral replication in the absence of antiretroviral therapy (ART) in some patients.6, 7 However, this approach failed in long‐term treatment when study subjects became refractory to IFN treatment and viral loads returned to previous levels."
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"The impact of HIRI on LCMV replication (see Fig. 6A and B) was evaluated by one-way analysis of variance with the Tukey's post hoc test.We have previously shown that USP18 can modulate the type 1 IFN response (14)."
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"ISG15 has also been shown to regulate type I interferon signalling by stabilizing USP18 (ref.4) and by interacting with leucine-rich repeat-containing protein 25 (LRRC25) to mediate the autophagic degradation of retinoic acid-inducible gene I protein (RIG-I; also known as DDX58)41."
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