IndraLab

Statements

CYLD inhibits JNK. 20 / 20
| 20
reach
"On the contrary, CYLD WT overexpression leads to a diminished JNK activation both in non stimulated and in TNF-alpha-stimulated A-CYLD WT cells (XREF_FIG)."
21900959
reach
"CYLD also negatively regulates the c-Jun N-terminal kinase (JNK) signaling pathway and mitogen activated protein kinase (MAPK) pathway, which are known to participate in a wide range of cellular processes, including proliferation, differentiation, and apoptosis of cholesteatoma [XREF_BIBR, XREF_BIBR]."
20414373
reach
"Here we show that liver specific disruption of CYLD triggers hepatocyte cell death in the periportal area via spontaneous and chronic activation of TGF-beta activated kinase 1 (TAK1) and c-Jun N-terminal kinase (JNK)."
22698400
reach
"These results establish a pivotal role for CYLD in controlling Tak1 function and explain how CYLD negatively regulates IKKbeta and JNK."
17548520
reach
"CYLD deletion causes accumulation of constitutively active TAK1, and its downstream kinases JNK and IKK, which results in T cells that become hyper-responsive to TCR stimulation."
28524749
reach
"CYLD, a de-ubiquitinating enzyme, suppresses both the NF-kappaB pathway [XREF_BIBR, XREF_BIBR] and the c-Jun N-terminal kinase pathway [XREF_BIBR - XREF_BIBR]."
32892208
reach
"While CYLD negatively regulates JNK activation by diverse stimuli, it exerts an inhibitory effect on NF-kappaB pathway by anti-CD40, LPS, and IL-1beta."
19800320
reach
"Expression of a non cleavable form of CYLD inhibited activation of the JNK pathway and expression of AP-1 target genes in a T-cell line, although CYLD silencing only minimally increased JNK activation [XREF_BIBR], possibly because of redundancy with other deubiquitinating enzymes."
26507244
reach
"CYLD, a tumor suppressor and a target gene of NF-κB, negatively regulates NF-κB and JNK activation by removing K63-linked polyubiquitin chains from TRAF2 and TRAF6 as well as several other signaling proteins [214,215]."
23758787
reach
"The loss of CYLD in both primary T cells and the Jurkat T cell line causes the constitutive activation of Tak1 as well as its downstream targets JNK and IKK."
17548520
reach
"Recent evidence demonstrates that CYLD negatively regulates the c-Jun N-terminal kinase (JNK) signaling pathway, a critical mediator of cell survival."
20347313
reach
"Conversely, loss of the K63 specific deubiquitinase CYLD causes spontaneous activation of IKK and JNK as well as their upstream kinase Tak1."
26260210
reach
"CYLD negatively regulates the activation of IKK and JNK, and its expression is markedly upregulated under conditions of RANKL induced osteoclastogenesis [XREF_BIBR]."
22216904
reach
"C-Jun N-terminal kinase (JNK) signaling pathway activated by TNF alpha, anti-CD40 antibody, IL-1 beta, and lipopolysaccharide is repressed by CYLD by reducing the activity of MKK7 and JNKK2, which is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17851586
reach
"The tumor suppressor CYLD antagonizes NF-kappaB and JNK signaling by disassembly of Lys63 linked ubiquitin chains synthesized in response to cytokine stimulation."
18313383
reach
"Depending on the cellular context CYLD has been shown to negatively regulate NF-kappaB and/or JNK signalling pathways resulting in suppression of cell proliferation and survival."
19893491
reach
"CYLD can suppress the activation of NF-κB or JNK signaling by removing K63-linked polyubiquitin chains from the signaling complex [27–29,40]."
30388174
reach
"Subsequent studies have demonstrated that CYLD negatively regulates nuclear factor kappa B (NF-kappaB) and c-Jun N-terminal kinase (JNK) pathways, and plays a critical role in immunity, lipid metaboli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19800320
reach
"However, because Cyld deficiency did not cause the activation of ERK, the target of CYLD might be an intermediate signaling factor specifically mediating the activation of JNK and IKKbeta."
17548520
reach
"CYLD, a tumor suppressor and a target gene of NF-kappaB, negatively regulates NF-kappaB and JNK activation by removing K63 linked polyubiquitin chains from TRAF2 and TRAF6 as well as several other signaling proteins [XREF_BIBR, XREF_BIBR]."
23758787