IndraLab

Statements

COPS5 activates DNA-templated transcription. 13 / 13
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"JAB1 activates JUN N-terminal kinase ( JNK ) to phosphorylate JUN and so functions as a co-activator of activator protein 1 ( AP1 ) - - a transcription factor that is implicated in cell growth , transformation and cell death54 ."
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"CSN5, the fifth CSN subunit, was initially identified as c-Jun-activation-domain binding protein-1 (Jab1) that mediates AP-1-dependent gene transcription via stabilization of c-Jun [4,5]."
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"Moreover, CSN5 silencing inhibited the secretion of TGF-beta, IL-1beta and IL-6 and the transcriptional activity of transcription factor NF-kappaB and Twist in human colorectal cancer cells."
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"Since the deletion of Csn5 leads to dramatically reduced transcription levels of DON biosynthesis-related genes, DON production in Δcsn5 and PH-1 was determined in this study."
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"One explanation could come from two studies reporting that CSN5 binds to the progesterone receptor in addition to SRC to mediate the transcription and / or have a synergistic effect with the transcription factor E2F1 [ 181,182,183 ] ."
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"We show that JAB1 binds directly to the HLH domain of HAND2 and increases HAND2 transcription stimulating activity."
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"Significantly, inhibition of CSN associated kinase activity or knockdown of CSN5 impairs JFK promoted p53 degradation, enhances p53 dependent transcription, and promotes cell growth suppression, G (1) arrest, and apoptosis."
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"This includes defining mechanisms whereby LFA-1 engagement enhances transcriptional activation of numerous genes by regulating its association with transcription modulators such as JAB-1, and through interaction with other gene activating signaling complexes such as JAK-STATs."
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"Human JAB1 (Jun activation domain binding protein 1) was first described as a coactivator of c-Jun and Jun D. JAB1 enhances the ability of c-Jun and Jun D to activate transcription by stabilizing comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, CSN subunits may act as monomers, and CSN5 can positively regulate several transcription factors, including NFkappaB, JUN/AP-1, Hif1alpha, and E2F1."
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"CSN5 enhances AP-1-mediated transcriptional activation by stabilizing complexes of the transcription factors c-Jun or JunD [9]."
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"JAB1 associates with beta2 integrins in lymphocytes and, upon alpha L beta 2 engagement, translocates into the nucleus and enhances c-Jun-driven transcription [2]."
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"As mentioned above, CSN5 was discovered as c-Jun-activation-domain binding protein JAB1, mediating AP-1-dependent gene transcription by stabilization of c-Jun [4,5]."
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