IndraLab

Statements

COPS5 activates transcription, DNA-templated. 12 / 12
| 2 10
eidos
"One explanation could come from two studies reporting that CSN5 binds to the progesterone receptor in addition to SRC to mediate the transcription and / or have a synergistic effect with the transcription factor E2F1 [ 181,182,183 ] ."
31195722
reach
"CSN5, the fifth CSN subunit, was initially identified as c-Jun-activation-domain binding protein-1 (Jab1) that mediates AP-1-dependent gene transcription via stabilization of c-Jun [4,5]."
28229932
reach
"As mentioned above, CSN5 was discovered as c-Jun-activation-domain binding protein JAB1, mediating AP-1-dependent gene transcription by stabilization of c-Jun [4,5]."
28229932
reach
"Human JAB1 (Jun activation domain binding protein 1) was first described as a coactivator of c-Jun and Jun D. JAB1 enhances the ability of c-Jun and Jun D to activate transcription by stabilizing comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10721695
reach
"Moreover, CSN5 silencing inhibited the secretion of TGF-beta, IL-1beta and IL-6 and the transcriptional activity of transcription factor NF-kappaB and Twist in human colorectal cancer cells."
26045788
reach
"JAB1 associates with beta2 integrins in lymphocytes and, upon alpha L beta 2 engagement, translocates into the nucleus and enhances c-Jun-driven transcription [2]."
12527355
reach
"We show that JAB1 binds directly to the HLH domain of HAND2 and increases HAND2 transcription stimulating activity."
15139020
reach
"Moreover, CSN subunits may act as monomers, and CSN5 can positively regulate several transcription factors, including NFkappaB, JUN/AP-1, Hif1alpha, and E2F1."
24196835
reach
"Significantly, inhibition of CSN associated kinase activity or knockdown of CSN5 impairs JFK promoted p53 degradation, enhances p53 dependent transcription, and promotes cell growth suppression, G (1) arrest, and apoptosis."
21127074
reach
"This includes defining mechanisms whereby LFA-1 engagement enhances transcriptional activation of numerous genes by regulating its association with transcription modulators such as JAB-1, and through interaction with other gene activating signaling complexes such as JAK-STATs."
12234372
eidos
"JAB1 activates JUN N-terminal kinase ( JNK ) to phosphorylate JUN and so functions as a co-activator of activator protein 1 ( AP1 ) - - a transcription factor that is implicated in cell growth , transformation and cell death54 ."
14502271
reach
"CSN5 enhances AP-1-mediated transcriptional activation by stabilizing complexes of the transcription factors c-Jun or JunD [9]."
22120635