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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Beta1 subunit inhibits KCNMA1. 2 / 2

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"The observation in XREF_FIG E that the beta1 subunit decreases the voltage sensitivity of Slo1 core and Slo3 tail channels, shifting V 0.5 10-20 mV positive (XREF_FIG F), suggests that the beta1 subunit is expressed and that it does associate in some manner with the Slo1 core and Slo3 tail channels."

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"Similarly to BKalpha subunit knockout, beta1 subunit ablation reduces BK channel activity in arterial myocytes, elevates arterial contractility and increases systemic blood pressure."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...