IndraLab

Statements

PSMC5 inhibits ATXN3. 2 / 2
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"In addition, several groups demonstrated that inhibition of the proteasome in cell culture and mammalian cells results in increased aggregation and cytotoxicity in SCA 3 and HD [XREF_BIBR, XREF_BIBR], whereas an overexpression of p45 (ATPase of 19S subunit of proteasome) stimulates degradation of ataxin-3 [XREF_BIBR]."
25309920
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"P45, an ATPase subunit of the 19S proteasome, interacts with ataxin-3 in vitro and stimulates the degradation of ataxin-3 in an in vitro reconstituted degradation assay system."
17302910