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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMC5 inhibits ATXN3. 2 / 2

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"In addition, several groups demonstrated that inhibition of the proteasome in cell culture and mammalian cells results in increased aggregation and cytotoxicity in SCA 3 and HD [XREF_BIBR, XREF_BIBR], whereas an overexpression of p45 (ATPase of 19S subunit of proteasome) stimulates degradation of ataxin-3 [XREF_BIBR]."

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"P45, an ATPase subunit of the 19S proteasome, interacts with ataxin-3 in vitro and stimulates the degradation of ataxin-3 in an in vitro reconstituted degradation assay system."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...