IndraLab

Statements

USP14 activates FAM126A. 7 / 7
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"The above results suggested USP14 promotes HCC cell proliferation partially in a HIF1-α-dependent manner."
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"Collectively, these data demonstrated that USP14 promoted HCC proliferation and tumor growth.To further verify whether ablation of USP14 or/and a selective deubiquitination activity inhibitor of USP14 (IU1) could restrain HCC growth in animals, we implanted subcutaneously USP14-depleted HCCLM3 cells stably expressing USP14-specific shRNA (shUSP14) or control shRNA (shCtrl) and monitored tumor growth as they were treated with IU1 or vehicle (Figure S4A, B)."
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"Additionally, USP14 depletion and its inhibitor IU1 significantly inhibited cell proliferation, migration, and angiogenesis in HCC, suggesting that USP14 might be a potential therapeutic target for HCC."
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"USP14 promotes tumor progress in HCC even under hypoxia conditions."
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"USP14 increases cell proliferation in HCC cell lines."
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"USP14 depletion or IU1 treatment suppresses HCC cell growth in mice."
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"USP14 enhances HIF1-alpha-mediated transactivation in HCC cells."
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