IndraLab

Statements

ZUP1 inhibits STING dimers. 2 / 2
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reach
"A previous report indicates that only the dimer form of STING is ubiquitinated [9], which coupled with our observation that PLPs with DUB activity reduce the accumulation of STING dimers, supports a role for DUB activity in negatively regulating STING."
22312431
reach
"Similar results were obtained when we evaluated PLpro-TM for disruption of STING dimers (Fig. S3) A previous report indicates that only the dimer form of STING is ubiquitinated [9], which coupled with our observation that PLPs with DUB activity reduce the accumulation of STING dimers, supports a role for DUB activity in negatively regulating STING."
22312431