IndraLab

Statements

USP5 activates apoptotic process. 13 / 13
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"USP5 deficiency also induces DNA damage, cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells."
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"In both w/t and mutant p53 expressing cells, Usp5 KD enhanced the onset or extent of apoptosis induced by vemurafenib, with evidence for activation of both the intrinsic and extrinsic pathway."
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"USP5 depletion suppressed NSCLC cell in vitro and in vivo growth and enhanced cell apoptosis."
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"On the other hand, some studies have also shown that USP5 promotes cell apoptosis."
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"To focus on the mechanisms by which USP5 regulates eye development, we first wanted to know whether apoptosis is induced by the knock-out of usp5, since there is a possibility that interference with the differentiation process leads to apoptosis."
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"It has been reported that USP5 is highly expressed in NSCLC and USP5 silencing inhibited NSCLC cell proliferation and induced cell apoptosis, cell autophagy, and cisplatin sensitivity."
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"Further functional investigation also showed that Usp5 knockdown suppressed cell proliferation, migration, drug resistance and induced apoptosis; on the other hand, Usp5 overexpression promoted colony formation, migration, drug resistance and tumorigenesis."
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"In the present study, our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8, which were initially showed to induce apoptosis in various cancers."
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"Similarly, ubiquitin-specific peptidase 5 (USP5) was significantly upregulated in EC tissues, whereas its inhibition could reduce the migration and proliferation ability of EC cells and induce cell cycle arrest and apoptosis."
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"In MM, knockdown of USP5 can suppress MM cell proliferation and survival, inducing apoptosis [20–22], suggesting that USP5 may be a key factor in promoting MM development."
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"In lipopolysaccharide-treated Huh-7 and HepG2 cells , USP5 knockdown increased cell viability , reduced apoptosis , and decreased the expression of inflammatory factors , including NLRP3 , IL-1beta , IL-18 , ASC , and procaspase-1 ."
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"Next, CCK-8 and flow cytometry analysis demonstrated that USP5 reduction obviously repressed cell viability and induced apoptosis in NCI-H929, INA-6 and U266 cells, and USP5 upregulation aggravated cell viability and repressed cell apoptosis of MM.1S cells (Fig. 2D, E, Fig. S2D, E)."
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"These chalcone derivatives effectively inhibit the activity of DUB, such as USP5, UCH-L3, USP2, UCH-L1, and USP8, leading to irreversible cell cycle arrest in breast, ovarian, and cervical cancer cells (IC50 = 1.5-12.5 µM), as well as inhibiting their proliferation and initiating apoptosis."
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