IndraLab

Statements

USP5 activates apoptotic process. 5 / 5
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"Further functional investigation also showed that Usp5 knockdown suppressed cell proliferation, migration, drug resistance and induced apoptosis; on the other hand, Usp5 overexpression promoted colony formation, migration, drug resistance and tumorigenesis."
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"In the present study, our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8, which were initially showed to induce apoptosis in various cancers."
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"To focus on the mechanisms by which USP5 regulates eye development, we first wanted to know whether apoptosis is induced by the knock-out of usp5, since there is a possibility that interference with the differentiation process leads to apoptosis."
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"In both w/t and mutant p53 expressing cells, Usp5 KD enhanced the onset or extent of apoptosis induced by vemurafenib, with evidence for activation of both the intrinsic and extrinsic pathway."
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"USP5 deficiency also induces DNA damage, cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells."
33643919