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USP8 activates poly-ubiquitin chains. 1 / 1

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"Stefan et al. discovered and structurally identified the first covalent inhibitor of NEDD4-1, which switches the mechanism of NEDD4-1 from processive to distributive, following which NEDD4-1 synthesizes the attachment of poly-ubiquitin chains to the substrate in the presence of the deubiquitinating enzyme USP8 ."

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USP8 activates poly-ubiquitin chains. 1 / 1

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