IndraLab

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COPS5 inhibits apoptotic process. 35 / 37
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"These findings suggest that CSN5 suppression may partially trigger cellular apoptosis via the direct activation of the ATF4-CHOP pathway."
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"By contrast, overexpression of Jab1 in CNE1 cells blocked cisplatin- and UV radiation induced apoptosis, as measured by Hoechst 33342 staining and analysis of PARP and caspase-3 cleavage."
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"Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells."
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"The constitutive deletion of Jab1 in mice results in early embryonic lethality by E8.5, with impaired proliferation and accelerated apoptosis, thus underscoring the essential role of Jab1 in overall early embryogenesis."
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"Jab1/CSN5 as an oncogene involved in NPC tumorigenesis and radioresistance by inactivating several tumor suppressors, increasing DNA repair ability, and suppressing radiation-induced apoptosis ( Wang [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"(Phospho)-beta-catenin levels were found to be reduced following CSN5 knockdown and CSN5 promoted CRC cell proliferation but also apoptosis [30]."
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"In a previous study, Jab1 deficiency in mice resulted in early embryonic death and increased radiation-induced apoptosis by spontaneous DNA damage and homologous recombination defects [18]."
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"Our results demonstrated that suppression of CSN5 expression in these cells could inhibit cell proliferation and promote apoptosis."
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"Silencing CSN5 triggers cancer cell apoptosis with significant up-regulation of p53 protein [XREF_BIBR, XREF_BIBR]."
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"The level of Bcl-XL upregulation was subtle and does not seem to be sufficient to suppress apoptosis mediated by Jab1 depletion."
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"Moreover, to validate whether knockdown of CSN5 could induce cell apoptosis via a p53-mediated pathway, we examined the expression levels of p53."
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"27 In the present study, we demonstrated that the expression of CSN5 was higher in gastric cancer tissues and gastric cancer cells, meanwhile, knockdown of CSN5 inhibited proliferation and induced apo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This data complements previous studies demonstrating that CSN5 loss inhibits proliferation and induces apoptosis [XREF_BIBR - XREF_BIBR]."
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"Thus, in our next experiments we determined whether loss of Jab1 promotes apoptosis of NPC cells in response to DNA damage."
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"Moreover, silencing Jab1 protein expression declined tumor growth and further increased the apoptosis rate of gastric cancer cells."
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"Likewise, Sang et al. have reported that inhibition of Jab1 and COPS5 promoted the apoptosis through p53 related apoptotic pathways in gastric cancer cells."
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"We also found that CSN5 silence inhibited cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells."
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"CSN5 can also promote cell proliferation and inhibit apoptosis by accelerating the nuclear export of p53 and inducing its degradation in a MDM2-mediated manner [38]."
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"Mechanistic investigation revealed that CSN5i-3 inhibited Jab1 expression and increased the expression of apoptosis marker cleaved caspase3 and cell cycle related protein p27 in BT474 and SKBR3 cells."
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"Additionally, our findings further demonstrate that silencing CSN5 arrested the cell cycle in G0/G1 phase and induced NSCLC cell apoptosis, indicating that CSN5 promotes NSCLC cell growth may be assoc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Sub-G1 DNA content analysis showed that JAB1 could accelerate apoptosis induced by BclGs overexpression and both BclGs and BclGs together with JAB1 induced apoptosis could be almost completely inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The GO term and KEGG pathway analysis is not only in accordance with that CSN5 participates in the carcinogenesis progression and has closely correlation with poor prognosis and cancer recurrence [ 17[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Positive staining using the TUNEL assay confirmed that loss of CSN5 could induce germ cell apoptosis."
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"Loss of Jab1 sensitized cells to gamma radiation induced apoptosis and increased spontaneous DNA damage and homologous recombination defects."
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"Rabbit anti-JNK and phosphorylated JNK were purchased from Cell Signaling Technology, Beverly, MA.To determine whether knockdown of JAB1 can enhance the apoptosis of RA FLSs treated with human TNF-α, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"3.1 CSN5 inhibition sensitizes EOC to platinum in vitro and in vivo and induces apoptosis in platinum-resistant EOC cells."
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"XREF_BIBR used T83 (a new 4-arylidene curcumin analogue) to inhibit the expression of Jab1 in NPC cells, demonstrating that inhibition of Jab1 could reduce tumor cell growth, induce G 2 / M arrest, and increase tumor cell apoptosis, thus enhancing the sensitivities of NPC cells to radiotherapy."
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"Several targets of Jab1 and CSN5, including p27, p53, c-myc, and cyclin E, were found to be highly expressed in Jab1 and CSN5 -/- embryos, resulting in impaired proliferation and accelerated apoptosis [XREF_BIBR, XREF_BIBR]."
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"Conditional deletion of Jab1 and CSN5 in thymocytes resulted in defective S-phase progression and increased apoptosis that could be attributed to CSN substrates, including p53, IkappaB-alpha, and beta-catenin."
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"However, there was no significant difference between the control and Jab1-siRNA treated groups; thus, we can not conclude that Jab1 knockdown initiates apoptosis under these conditions."
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"Jab1 and CSN5 knockdown also impaired proliferation and enhanced apoptosis in these cells regardless of the genotype of the tumor suppressor p53 [XREF_BIBR]."
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"Jab1 and COPS5 knockdown significantly inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells."
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"In the present study, both genetic and pharmacological suppression of CSN5 enhanced the cellular apoptosis of DDP cells, an effect that was amplified with cisplatin treatment."
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"Indeed, the constitutive deletion of Jab1 in mice results in early embryonic lethality by E8.5 with impaired proliferation and increased apoptosis (Tian et al., 2010; Tomoda, Yoneda-Kato, Fukumoto, Yamanaka, & Kato, 2004)."
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"Jab1 and CSN5 inhibits cisplatin- and radiation- induced apoptosis of NPC cells."
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