IndraLab

Statements

USP18 inhibits DDX58. 2 / 2
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reach
"Immunofluorescence analysis using specific dsRNA antibodies showed a significant and time-dependent accumulation of dsRNA in the USP18 KO cells after IFN treatment, indicating that USP18-dependent ISGylation under these conditions could inhibit ADAR activity.In addition to ADAR, PKR, RIG-I and MDA5, we found other proteins involved in antigen presentation and resistance to immunotherapy, such as TAP1, GBP1, STAT1, IFIT1, PSMB10, PSMB9, GBP2, MAGE and PARP14, also regulated by USP18-dependent ISGylation."
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reach
"It would be interesting to know if duck USP18 can negatively regulate RIG-I signaling by removing the K63-linked ubiquitin chains furnished by TRIM25."
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