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USP11 activates ferroptosis. 12 / 12
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"Overexpression of USP11 significantly ameliorate oxidative stress-induced ferroptosis, thus relieving IVDD by increasing Sirt3."
37099926
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"Specifically, we found that USP11 enhances breast cancer progression and ferroptosis through PGAM5."
39300548
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"Furthermore, the deubiquitinating enzyme USP11 promotes autophagy-dependent ferroptosis by stabilizing BECN1, leading to ferroptosis-mediated spinal cord ischemia-reperfusion injury [163]."
38955112
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"What accords with previous studies is that overexpression of Sirt3 could ameliorate IVDD induced by USP11 deletion [84], which indicates that the stability of Sirt3 is essential for regulatory effect of USP11 on oxidative stress-induced ferroptosis in IVDD.In conclusion, ferroptosis is associated closely with the process of IVDD."
37099926
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"The decreased autophagy markedly weakened the ferroptosis mediated by USP11 and autophagy induction had a synergistic effect with USP11."
34839355
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"Zhu et al39 demonstrated that the deubiquitinase USP11 stabilized SIRT3 to inhibit oxidative stress-induced ferroptosis in human NP cells."
39583856
eidos
"Interestingly , upregulating the expression of USP11 also appeared to increase the production of autophagosomes and to cause substantial autophagic flux , a potential mechanism through which USP11 may enhance ferroptosis ."
34839355
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"Indeed, USP11 is a recently identified cysteine protease DUBs as the NRF2 target in NSCLC cells and knockdown of USP11 expression sensitized NSCLC cells to ROS-induced ferroptosis [19]."
36358651
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"Knockdown of USP11 in vitro and KO of USP11 in vivo (USP11 -/Y ) significantly decreased neuronal cell ferroptosis."
34839355
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"Interestingly, upregulating the expression of USP11 also appeared to increase the production of autophagosomes and to cause substantial autophagic flux, a potential mechanism through which USP11 may enhance ferroptosis."
34839355
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"Conversely, the inhibition of autophagy attenuated USP11-mediated ferroptosis, which was beneficial to functional recovery in SCIRI."
35481263
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"Inhibition of USP11 disrupts Sirt3 to promote oxidative stress-induced ferroptosis and aggravate IVDD (Zhu et al., 2023a)."
37576601