IndraLab

Statements


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"Interestingly, upregulating the expression of USP11 also appeared to increase the production of autophagosomes and to cause substantial autophagic flux, a potential mechanism through which USP11 may enhance ferroptosis."

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"The decreased autophagy markedly weakened the ferroptosis mediated by USP11 and autophagy induction had a synergistic effect with USP11."

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"Knockdown of USP11 in vitro and KO of USP11 in vivo (USP11 -/Y ) significantly decreased neuronal cell ferroptosis."

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"Overexpression of USP11 significantly ameliorate oxidative stress-induced ferroptosis, thus relieving IVDD by increasing Sirt3."

eidos
"Interestingly , upregulating the expression of USP11 also appeared to increase the production of autophagosomes and to cause substantial autophagic flux , a potential mechanism through which USP11 may enhance ferroptosis ."