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CYLD binds SMAD7. 16 / 17
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"Their data showed that expression of spliceosome of CYLD (sCYLD) and Smad7 in the colonic mucosa lamina propria T cells of CD patients was increased and correlated with disease severity."
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"These results establish a physiological interaction between Smad7 and CYLD."
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"CYLD binds to Smad7."
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"We next examined whether CYLD and Smad7 can form a complex under endogenous conditions."
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"We next examined whether CYLD and Smad7 can form a complex under endogenous conditions."
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"These results establish a physiological interaction between Smad7 and CYLD."
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"Following TGF-beta stimulation in WT primary CD4 + cells, interaction between Smad7 and CYLD was readily detected by co-immunoprecipitation using anti-Smad7 antibody and immunoblotting with anti-CYLD antibody."
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"To further investigate the interaction between CYLD and Smad7, we analyzed the ubiquitination of endogenous Smad7 in TGF-beta-stimulated T cells."
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"Finally, we found that Smad7 is Lys-63-polyubiquitinated in both T cells and HeLa cells following TGF-beta stimulation and that CYLD binds to Smad7 in T cells under endogenous conditions to modulate the polyubiquitination of Smad7."
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"CYLD binds to Smad7."
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"This showed that CYLD can bind to SMAD7 and deubiquitinate SMAD7 at Lysine 360 and 374 residues, which are required for the activation of TAK1 and p38 signaling (Zhao et al., xref )."
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"Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues."
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"Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues."
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"To further investigate the interaction between CYLD and Smad7, we analyzed the ubiquitination of endogenous Smad7 in TGF-β-stimulated T cells."
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"Following TGF-β stimulation in WT primary CD4 + cells, interaction between Smad7 and CYLD was readily detected by co-immunoprecipitation using anti-Smad7 antibody and immunoblotting with anti-CYLD antibody."
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"Similarly, CYLD-Smad7 interaction was clearly detected in the reverse immunoprecipitation with an anti-CYLD antibody followed by immunoblot analysis with anti-Smad7 antibody ( xref , C and D )."
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