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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

JAK2 phosphorylates STAT3 at position 705. 3 / 3

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"In primary epithelial cells, oxidized palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine activates tyrosine kinase JAK2, which in turn phosphorylates STAT3 on residue 705."

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"It is currently well characterized that the inflammatory induction of hepcidin expression is mainly mediated by IL-6, which binds to the IL-6 receptor and gp130 and then recruits Janus kinase 2 (JAK2) to phosphorylate STAT3 at tyrosine residue 705 [XREF_BIBR, XREF_BIBR]."

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