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PRMT1 methylates USP11. 4 / 4
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"Indeed, the finding that the methylation of USP11 catalysed by PRMT1 was completely abolished by the R433K mutation strongly implies that at least in vitro, this is the sole residue targeted by PRMT1."
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"Given that some PRMT-interacting proteins are cofactors rather than substrates , we conducted in vitro methylation assays and confirmed that GST-PRMT1 can directly methylate recombinant human USP11 (Fig. 1b)."
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"USP11 is methylated by PRMT1."
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"Methylated USP11 then promotes PRMT1 activity towards MRE11 that enables DNA end-resection and RPA loading (Fig. 7g)."
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