IndraLab

Statements

NOP53 activates USP15. 3 / 3
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"Interestingly, we detected that reduction of endogenous GLTSCR2 resulted in increased USP15 activity in removing K48-linked ubiquitination of RIG-I-N in GLTSCR2 knockdown cells (Fig. 6d, lane 6) , whereas GLTSCR2 presence reduced the activity of USP15 in removing K48-linked ubiquitination of RIG-I-N in HEK293T cells (lane 3)."
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reach
"Our studies revealed a novel role the nucleolar protein GLTSCR2 played in attenuation of IFN-β , via cytoplasmic translocation to induce the ability of USP15 to deactivate RIG-I."
27824081
reach
"Our studies revealed a novel role the nucleolar protein GLTSCR2 played in attenuation of IFN-beta, via cytoplasmic translocation to induce the ability of USP15 to deactivate RIG-I."
27824081