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COPS5 activates AP1. 22 / 26
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"He et al. reported that the site-directed mutagenesis of either cysteine in the CXXC active site into serine (Cys/Ser) not only inactivated the enzyme, but also inhibited c-Jun phosphorylation and fai[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20816831
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"JAB1, the fifth subunit of CSN, is a co-activator of AP-1, which has been shown to interact with a variety of cytokines, growth factors or nuclear receptors."
15304329
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"As an intracrine factor, the intracellular function of HPO is to increase c-Jun phosphorylation independent of c-Jun amino-terminal kinase (JNK), extracellular signal regulated kinase (ERK) -1 and -2, and leads to potentiation of JAB1 mediated AP-1 activation."
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"In this study, we found that hAPH2 could antagonize the activation of AP-1 induced by JAB1 in COS-7 cells, but we are not able to find whether this negative effect on AP-1 activity is JAB1 dependent o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17123647
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"MIF inhibits Jab1- and stimulus enhanced AP-1 activity, but does not interfere with the induction of the transcription factor NFkappaB."
11089976
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"MIF inhibits JAB1 and CSN5 mediated AP-1 activity and reduces JNK activity stimulated by JAB1 and CSN5."
11932196
eidos
"The binding of MIF with JAB1 / CSN5 also modulates AP-1 activity and cell proliferation by inactivation of p53 [ 8] ."
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"Interestingly, JAB-1 does not appear to potentiate AP-1 activity after TCR stimulation (unpublished data)."
14707112
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"MIF increases the transcription of MMP-1/3 by inhibiting the activity of Jab1 and CSN5 mediated AP-1 and the translation of TNF dependent blocking of JNK and SAPK activity stimulated by Jab1 and CSN5 [54,56]."
29856236
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"Trx interaction with Jun activation domain-binding protein 1, Jab1, was implicated in the downregulation of Jab1 functions, such as Jab1-induced AP-1 activation and Jab1-dependent degradation of cell [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22910298
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"Given that hAPH2 could interact with JAB1, we further investigated whether hAPH2 could modulate JAB1 induced AP-1 activity."
17123647
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"In this study, we found that hAPH2 could antagonize the activation of AP-1 induced by JAB1 in COS-7 cells, but we are not able to find whether this negative effect on AP-1 activity is JAB1 dependent o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17123647
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"JAB1-mediated AP-1 activation is also regulated by other JAB1 binding partners."
37365502
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"HPO site directed mutants (Cys and Ser) at active sites, which lost sulfhydryl oxidase activity, could not increase c-Jun phosphorylation and failed to potentiate JAB1 mediated AP-1 activation."
14500725
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"MIF would thereby inhibit Jab1 enhanced AP-1 transcriptional activity [XREF_BIBR]."
19413900
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"We therefore examined whether NRBP, through its binding to Jab1, might modulate the Jab1-mediated AP-1 activation in mammalian cells."
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"Moreover, a recent report has implicated Jab1-mediated AP-1 induction in proper T cell activation [17] ."
17052710
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"To determine whether NRBP regulated the Jab1 function by affecting the level of phosphorylation of c-Jun, we then examined the levels of c-Jun and phosphorylated c-Jun in 293T cells in a similar cotra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17052710
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"In addition, LFA-1 engagement is followed by an increase of the nuclear pool of a transcriptional coactivator Jun activation domain binding protein 1 that modulates AP-1 activity."
14676297
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"Trx interaction with Jun activation domain-binding protein 1, Jab1, was implicated in the downregulation of Jab1 functions, such as Jab1-induced AP-1 activation and Jab1-dependent degradation of cell [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22910298
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"Furthermore, the data indicated that E9730 appeared to enhance Jab1 induced AP-1 activity in a concentration dependent manner and Jab1 may be involved in the intracellular signaling transduction from E9730 to AP-1."
14732868
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"COPS5 was initially cloned as a Jun activation domain-binding protein 1, and functions as a c-Jun or JunD co-activator to enhance AP-1 complex activity [ 7 ]."
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