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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

KCNMA1-Y255A inhibits dihydrogen. 2 / 2

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"We found that this mutant was also located in nonacidic vacuoles, suggesting that NADase is not required for inhibition of acidification and that insertion of SLO (Y255A) is sufficient to disrupt the phagolysosomal proton gradient."

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"The fact that infection with the slo (Y255A) mutant impairs phagolysosomal acidification but has minimal effects on galectin 8 binding implies that damage to the vacuolar membrane caused by insertion of the SLO (Y255A) prepore complex is sufficient to at least partially disrupt the proton gradient but insufficient to expose inner membrane galactosides to the cytosol."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...