IndraLab

Statements

USP15 inhibits REST. 4 / 12
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"Indeed, USP15 depletion impaired the normal periodic accumulation of REST in early G 1, suggesting that it plays an important role in cellular REST homeostasis."
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"We conclude that depletion of USP15 reduced the level of nuclear 220 kDa REST in both HEK-293T and A549 cells, not through accelerating its degradation, but rather through diminishing the supply of newly synthesized REST available to replenish its levels."
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"However, USP15 depletion does not destabilize pre-existing REST, but rather specifically impairs de novo REST synthesis."
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"Although one USP15 targeting sequence did diminish the REST transcript, importantly this was not observed with another individual siRNA that also reduced REST protein abundance, or with the siRNA pool used in the initial screen."
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