IndraLab

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FGF13 inhibits SCN9A. 2 / 3
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"FHF2B shifts the voltage-dependence of activation to more positive potentials, which might possibly lead to a decreased excitability of FHF2B expressing neurons.3.5 FHF2 shifts steady-state inactivation of Nav1.7 to more depolarized potentials in HEK293 cells."
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"Knockdown of FHF2 in DRG neurons, however, enhanced repriming of Nav1.7 (this study) and Nav1.6 channels (Rush et al., 2006) which suggest that these two channels could also contribute to the faster repriming of the TTX-S current in injured neurons."
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