IndraLab

Statements

FGF13 inhibits SCN9A. 3 / 3
1 | 2
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
reach
"FHF2B shifts the voltage-dependence of activation to more positive potentials, which might possibly lead to a decreased excitability of FHF2B expressing neurons.3.5 FHF2 shifts steady-state inactivation of Nav1.7 to more depolarized potentials in HEK293 cells."
31223136
reach
"Knockdown of FHF2 in DRG neurons, however, enhanced repriming of Nav1.7 (this study) and Nav1.6 channels (Rush et al., 2006) which suggest that these two channels could also contribute to the faster repriming of the TTX-S current in injured neurons."
31223136