IndraLab

Statements

UCHL5 inhibits Ubiquitin. 7 / 8
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"By contrast, USP14 and UCHL5 are located further from the 20S core and antagonize degradation by removing Ub in a stepwise manner from the distal end, promoting substrate dissociation from the proteasome 17.The human genome encodes for approximately 90 DUBs, which fall into six classes 18, 19."
28196299
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"It has been reported that both USP14 and UCH37 prevent substrate degradation by removing ubiquitin chains and promoting proteasomal substrate dissociation."
28018215
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"Functional studies suggest that UCH-37 inhibits the degradation of ubiquitinated proteins by the proteasome by removing ubiquitin from the distal end of the polyubiquitin chain."
19489724
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"By contrast, USP14 and UCHL5 are located further from the 20S core and antagonize degradation by removing Ub in a stepwise manner from the distal end, promoting substrate dissociation from the proteasome [17] ."
28196299
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"Since Uch37 is expected to disassemble ubiquitin chains at hRpn13 in the proteasome, we hypothesized that RA190 inactivation of Uch37 could impair the disassembly and clearance of ubiquitin chains from the proteasome."
28598414
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"Mechanistically, loss of Uch37 activity at the proteasome would cause ubiquitin chains to become stalled at hRpn13 in the proteasome (XREF_FIG, right panel)."
28598414
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"The degradation of Ub itself is closely related to the activities of DUBs associated with the proteasome since the loss of USP14 (or Ubp6 in yeast) or UCH37 has been shown to trigger degradation of Ub along with its target substrates, leading to depletion of the free Ub pool XREF_BIBR - XREF_BIBR."
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