IndraLab

"Here we introduce a new technique to monitor voltage-dependent charge displacement associated with Sh B-IR K + ion channels using RF electric fields during TEVC."

"The voltage-dependent formation of alamethicin ion channels has been described by different models [ 9 ]."

"In contrast to the single inhibition pathway induced by direct voltage-dependent interactions between Gβγ subunits and ion channels, there appear to be multiple pathways that induce voltage-independent inhibition of neuronal Ca 2+ current via a number of second messengers and protein kinases [ xref , xref , xref ]."

"It was reported that pllp could form voltage-dependent and K(+)-selective ion channels in the membrane, or act as entry receptor for a kind endogenous retrovirous xref ."

"The addition of a crude preparation of purified plasmolipin to lipid bilayers was able to induce the formation of voltage-dependent and potassium-selective ion channels in vitro ( Tosteson and Sapirst[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Some of the interactions that are relevant from this study’s point of view are as follows: (1) low-density lipoprotein receptor-related protein (LRP) is an important receptor for apolipoprotein E in the brain and is responsible for apolipoprotein E trafficking in the neuronal cells. xref LRP is co-expressed with Apo E since it is the primary receptor for lipidated form of Apo E; (2) voltage-dependent ion channel interaction affects intra-neuronal Ca2+ concentration, thereby affecting dopamine release to into the synapse in Parkinson’s disease; (3) α-synuclein is involved in aggregation to form inclusion bodies called as Lewy body and is a pathological hall mark of Parkinson’s disease. xref xref – xref There is association between α-synuclein-related neurotoxicity and increased apolipoprotein E levels in Parkinson’s disease. xref "

"The formation of hippocampal synapses is associated with increased expression and activation of ligand-gated ion channels and voltage-dependent Ca 2+ channels, which increases the energy demand required to operate the ion-motive ATPases that restore the membrane potential xref ."

"It is therefore of interest to determine whether other members of Type-II positive allosteric modulator family facilitate similar voltage-dependent interactions between α7 nicotinic receptor-mediated ion channels and charged compounds including those (i.e., choline and bicuculline) tested in this study."