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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

CD8 inhibits CYLD. 2 / 2

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"However, the parasite load in the CD8 + T cell depleted Cyld -/- mice was always lower compared to CD8 + T cell depleted WT mice, indicating that in addition to the contribution of CD8 + T cells the enhanced parasite control in the Cyld -/- mice is also mediated by other cell types, likely Cyld -/- macrophages and granulocytes."

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"Although our CD8 + T cell depletion experiments show the importance of CD8 + T cells in the control of PbA blood parasites, CD8 + T cell depleted Cyld -/- mice harbored lower parasite loads compared to CD8 + T cell depleted WT mice, indicating that the enhanced parasite control in the Cyld -/- mice is also mediated by other immune cells in addition to CD8 + T cells."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...