IndraLab

Statements

UCHL1 activates BDNF. 3 / 3
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"We found that UCHL-1 restored BDNF and TrkB transport not only in the presence of Abeta but also with IL-1beta, suggesting the two agents share a common mechanism of interfering with ubiquitination dependent trafficking mechanisms."
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"Based on our previous findings that UCH-L1 rescues BDNF and TrkB retrograde transport deficits induced by Abeta [XREF_BIBR], we believe UCH-L1 is a mechanistically interesting and relevant protein of interest."
28153028
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"We previously demonstrated that impaired retrograde transport in the presence of Abeta occurs through an ubiquitin dependent mechanism, and that the deubiquiting enzyme UCHL-1 restores retrograde transport of BDNF and TrkB [XREF_BIBR]."
28153028