IndraLab

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USP1 activates WDR48. 8 / 9
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"Moreover, we verified that (i) UAF1-USP1 is no more effective than UAF1 in the D-loop reaction (XREF_SUPPLEMENTARY), and (ii) USP1 fails to restore functional synergy of the UAF1 EEA mutant with RAD51AP1 (XREF_SUPPLEMENTARY)."
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"Moreover, we verified that UAF1-USP1 is no more effective than UAF1 in the D-loop reaction and that USP1 fails to restore functional synergy of the UAF1 EEA mutant with RAD51AP1."
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"The possibility that the NLS inactivating mutations might simultaneously interfere with UAF1 binding can not be formally ruled out, but these results suggest that the inability of USP1 (235-408) to promote UAF1 relocation can not be ascribed to competition with the nuclear import machinery."
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"Further studies of the USP1/UAF1 inhibitors suggested that pimozide and GW7647 inhibit USP1/UAF1 by a non‐competitive mechanism and bind at a site other than the active site of USP1/UAF1 [113]."
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"Moreover , WDR48 was significantly reduced by USP1 knockdown in MHCC97H and SK-Hep-1 cells ( Figure 10B , C , E , F ) ."
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"USP1, the major DUB of FANCD2 and FANCI, inactivates these two proteins mediated by the USP1 activating factor UAF1 once DNA damage repair is finished [XREF_BIBR]."
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"This assay is based on the nuclear accumulation of UAF1 induced by USP1 co-expression and, by using fluorescently tagged versions of these proteins, the results can be observed in live cells, before processing for microscopy analysis."
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"Moreover, WDR48 was significantly reduced by USP1 knockdown in MHCC97H and SK‐Hep‐1 cells (Figure 10B,C,E,F)."
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