IndraLab

Statements

Phosphorylated IGF1R leads to the phosphorylation of IRS1. 2 / 2
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reach
"XREF_BIBR, XREF_BIBR The ligand mediated phosphorylation of IGF1R leads to the recruitment and phosphorylation of insulin receptor substrate IRS-1 and IRS-2, which in turn results in the activation of PI3K and AKT signaling for cell proliferation and survival."
24292683
reach
"Binding of IGF1 to its receptor leads to phosphorylation of IGF1R, which further leads to phosphorylation and recruitment of the insulin receptor substrate-1 (IRS-1) and PI3K, consequently resulting in activation of downstream signaling components like AKT and MAPK pathways."
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