IndraLab

Statements

Phosphorylated IGF1R leads to the phosphorylation of IRS1. 2 / 2
| 2
reach
"Binding of IGF1 to its receptor leads to phosphorylation of IGF1R, which further leads to phosphorylation and recruitment of the insulin receptor substrate-1 (IRS-1) and PI3K, consequently resulting in activation of downstream signaling components like AKT and MAPK pathways."
32659913
reach
"XREF_BIBR, XREF_BIBR The ligand mediated phosphorylation of IGF1R leads to the recruitment and phosphorylation of insulin receptor substrate IRS-1 and IRS-2, which in turn results in the activation of PI3K and AKT signaling for cell proliferation and survival."
24292683