IndraLab

Statements

MDM2 binds CDKN1A, BBC3, and TP53. 4 / 4
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"ChIP assays from HCT116 p21 −/− cells show binding of p53 at CDKN1A , MDM2 , and BBC3 which served as positive controls, but not at the promoters of Survivin , CDC25C , and PLK1 (Figure xref )."
26595675
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"MDM2 suppression was associated with a marked increase in p53 and p53 effector genes p21 and PUMA transcript levels ( xref )."
27882940
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"Consistent with this idea, silencing of Mage-A expression leads to upregulation of several p53-responsive genes in a p53-dependent manner and stimulates by several fold the interaction of p53 with the p21, MDM2, and PUMA promoters."
21056992
sparser
"Treatment was associated with P53 stabilization and induction of MDM2, P21, and PUMA expression [ xref ]."
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