A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

TP53 binds CDKN1A, BBC3, and MDM2. 4 / 4
| 4
"ChIP assays from HCT116 p21 −/− cells show binding of p53 at CDKN1A , MDM2 , and BBC3 which served as positive controls, but not at the promoters of Survivin , CDC25C , and PLK1 (Figure xref )."
"MDM2 suppression was associated with a marked increase in p53 and p53 effector genes p21 and PUMA transcript levels ( xref )."
"Treatment was associated with P53 stabilization and induction of MDM2, P21, and PUMA expression [ xref ]."
"Consistent with this idea, silencing of Mage-A expression leads to upregulation of several p53-responsive genes in a p53-dependent manner and stimulates by several fold the interaction of p53 with the p21, MDM2, and PUMA promoters."