IndraLab

Statements

USP22 deubiquitinates Histone. 9 / 9
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"USP22 deubiquitylates histone and non histone substrates and has been associated with cancer progression and spinocerebellar ataxia."
27057639
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"USP22 deubiquitinates histone H2Bub and H2Aub."
25108806
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"USP22 can deubiquitylate both histone and non‐histone substrates."
40341781
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"USP22 reverses the polycomb-catalyzed ubiquitination of histones, including H2A and H2B, as well as nonhistone protein TRF1 (TBP [TATA box-binding protein]-related factor 1) to regulate the transcript[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22542455
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"In addition to histones, USP22 deubiquitinates TRF1, CCNB1, CCND1, and SIRT1, thereby regulating involvement in metabolism, cycling, and apoptosis."
35935969
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"Our studies indicate that USP22 acting as a histone deubiquitinase participates in deubiquitination of histone H2Bub on the promoter of VEGFA, co-activating ZEB1-mediated VEGFA transcription.It has been reported that ubiquitination modification on ZEB1 involved in maintenance of ZEB1 stability plays important roles in tumor progression."
36906615
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"However, the mechanisms by which miR-30e-5p regulates NSCLC pathogenesis remain unclear.Ubiquitin-specific peptidase 22 (USP22) is part of a multiprotein complex and regulates gene transcription withi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29174979
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"USP22 also deubiquitinates non histone proteins, including telomeric repeat binding factor 1 (TRF1), sirtuin 1 (SIRT1), cyclin B1 and others, leading to protein stabilization by preventing proteasome mediated degradation."
33777217
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"In addition, certain non histone proteins such as sirtuin 1 (Sirt1) and fructose-bisphosphatase 1 (FBP1) could be deubiquitinated by USP22."
28567015