IndraLab

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USP7 increases the amount of CHEK1. 3 / 3
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"Together, these experiments show that genetic or pharmacological inhibition of USP7 decreases CHK1 protein levels in three different leukemic cell lines, independently of p53 status, which demonstrates the role of USP7 deubiquitinase activity on CHK1 stability.To complete our investigation, experiments were performed to test whether the half-life of CHK1 is regulated by USP7 in leukemic cells."
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"Together, these experiments show that genetic or pharmacological inhibition of USP7 decreases CHK1 protein levels in three different leukemic cell lines, independently of p53 status, which demonstrates the role of USP7 deubiquitinase activity on CHK1 stability."
32447346
reach
"Importantly, wild type, but not catalytic mutant USP7 can deubiquitinate Chk1 in vivo and in vitro, confirming that USP7 directly regulates Chk1 protein levels."
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