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USP7 activates cell population proliferation. 127 / 129
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"In particular, disrupting USP7 activity might represent a direct β-catenin-targeting mechanism in AML given USP7’s known regulation of β-catenin stability [146,147], and recent evidence demonstrating that USP7 inhibition (both genetic; siRNA, and pharmacological; P22077) reduces AML cell proliferation and enhances chemosensitivity [148]."
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"Our finding suggests that EZH2, a tumorigenesis-related gene, can change transcriptional profile by abnormally establishing facultative heterochromatin at euchromatic regions.Both STAT3 and USP7 promote cell proliferation and prevent apoptosis [ [23,[30], [31], [32]]], and are advantageous to cancer cells’ survival."
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"Overall, these data indicate that expression of USP7 in the somatic cell lineage is necessary for granulosa cell differentiation and proliferation as no follicle beyond the stage of primordial was identified in mutants.In adults, no ovarian structures could be found in 8-week-old Usp7 ;Sf1:Cre mice, and the oviduct terminated with the infundibulum tip (Fig. 5C and movie S1), indicating complete degeneration of the ovary in the absence of Usp7."
eidos
"42 It has also been shown that both up or down-regulation of USP7 protein expression reduces cell proliferation in colon cancer and tumour development in vivo , as a consequence of increasing p53 levels.43 Interleukin-6 ( IL-6 ) stimulates STAT3 activation in normal physiological conditions and is controlled via negative feedback mechanisms ."
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"Moreover, USP7 overexpression increased the proliferation rate (Figure 3B) and enhanced the colony forming ability of hBMSCs (Figure 3C), suggesting that USP7 overexpression increases the self-renewal capacity of hBMSCs.Next, hBMSCs were transfected with USP7 overexpression vector, and osteogenic, adipogenic, and chondrogenic differentiation was induced for 14 days."
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"As shown in Fig. 5, PDGF triggered a 1.98-fold increase in cell proliferation compared with control (P < 0.05), while knockdown of USP7 by siRNA transfection dramatically suppressed PDGF-induced PASMCs proliferation from 1.98-fold to 1.51-fold over control (P < 0.05 versus PDGF-treated cells), pre-silencing of MDM2 also reversed the effect of PDGF on cell proliferation from 1.98-fold to 1.51-fold over control (P < 0.05 versus PDGF-treated cells), whereas non-specific siRNA did not affect PDGF-induced cell proliferation."
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"Our study indicated that MDM2 was up-regulated; this was accompanied with down-regulation of FoxO4, elevation of CyclinD1 and cell proliferation in PASMCs stimulated with PDGF, while knockdown of USP7 attenuated the changes of MDM2, FoxO4 and CyclinD1 as well as PASMCs proliferation caused by PDGF."
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"Notably, overexpression of USP7 has been detected in multiple myeloma, neuroblastoma, hepatocellular carcinoma, prostate cancer, breast cancer, and ovarian cancer, in which inhibition of USP7 suppresses proliferation and induces death of cancer cells independently of their p53 status."
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", In the present study, we found that PDGF increased the expression of USP7; silencing of USP7 attenuated PDGF-induced PASMCs proliferation, suggesting that USP7 mediates PDGF-stimulated PASMCs proliferation.USP7 has been reported to deubiquitinate several targeted proteins such as MDM2, UHRF1, DNMT1, claspin and PTEN, and thereby suppress their ubiquitinated degradation or the regulation of their subcellular localization."