IndraLab

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USP7 activates cell population proliferation. 56 / 58
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"USP7 silencing in HL-60 cells significantly reduced cell proliferation by increasing apoptotic cell death and the proportion of cells in the G1 phase."
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"Additionally , the USP7 inhibitor reduced cell proliferation , induced caspase activity and PARP cleavage , and arrested colon cancer cells in G1 ."
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"USP7 knockdown in colorectal cancer cells with varied TP53 status inhibits proliferation, further demonstrating that USP7 's effects can be independent of p53 [XREF_BIBR]."
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"In this study, we show that knockdown of Usp7 inhibits the proliferation and migration of MB cells, while Usp7 overexpression exerts an opposite effect."
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"Furthermore, silencing of USP7 in 786-O ARMC5 -/- cells abrogated the enhanced cell proliferation (P =.196)."
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"The above evidence revealed that FOXO6 upregulated the expression of USP7 in EC to inhibit the apoptosis of tumor cells and promote their proliferation."
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"USP7 promoted cell proliferation, migration, invasion in vitro and tumor growth by stabilizing TAZ."
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"In particular, genetic disruption of USP7 greatly reduced cell proliferation and chemoresistance in vitro and prevented PDAC growth in vivo."
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"USP7 knockdown inhibits the proliferation of CRC cells with different p53 status, and USP7 inhibition by its inhibitor P5091 attenuates the activity of Wnt signaling via enhanced ubiquitination and the subsequent degradation of beta-catenin."
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"In this study, we first showed that pharmacological or RNA interference mediated inhibition of USP7 significantly reduced AML cell proliferation in vitro and in vivo, impaired replication fork progression and increased AML cell death."
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"Thus, these findings support that restoration of USP7 underlies the anti-osteogenic effect of miR-15b by stimulating osteoblast proliferation, differentiation, and autophagy."
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"USP7 promoted cell proliferation , migration , invasion in vitro and tumor growth by stabilizing TAZ ."
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"42 It has also been shown that both up or down-regulation of USP7 protein expression reduces cell proliferation in colon cancer and tumour development in vivo , as a consequence of increasing p53 levels.43 Interleukin-6 ( IL-6 ) stimulates STAT3 activation in normal physiological conditions and is controlled via negative feedback mechanisms ."
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"Previous reports demonstrated that loss of USP7 through knockout leads to decreased proliferation of the respective cell line XREF_BIBR."
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"23, 24, 25 NSCLC studies have shown that high expression levels of USP5 and USP7 in lung cancer tissue promote lung cancer cell proliferation by stabilizing beta-catenin."
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"In OSCC cells , USP7 was shown to promote cell proliferation , inhibit apoptosis , enhance cell migration and invasion , and activate the Akt / ERK pathway ."
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"USP7 promoted the proliferation of mesangial cells and mesangial matrix, and stabilized the JMJD3 protein via deubiquitination in SV40 MES 13 cells."
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"Encouraged by the observation that the knockdown of USP7 inhibited the proliferation of T-ALL cells, we next evaluated the effect of the USP7 inhibitor P22077 on cell viability in four T-ALL cell lines."
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"Cellular studies showed that USP7 could enhance the proliferation, migration, and invasion capacities of HCC cells, thereby promoting tumor progression."
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"Furthermore, our cellular experiments showed that USP7 can directly enhance the proliferation and invasion of HCC cells, demonstrating its potential as a drug target."
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"USP7 promotes the proliferation of non-small cell lung cancer cell via stabilizing Ki-67 protein (Zhang et al., 2016)."
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"EdU staining revealed that overexpression of USP7 enhanced cell proliferation of osteoblasts, which was restored by and the addition of si-KDM6B (P <.05)."
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"Our results indicated that PDGF up-regulated USP7 protein expression and stimulated PASMCs proliferation; this was accompanied with the increase of MDM2, forkhead box O4 (FoxO4) reduction and elevation of CyclinD1."
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"Accordingly, we conducted cellular experiments using 2 human HCC cell lines; both showed that high expression of USP7 can promote tumor cell proliferation and invasion."
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"Notably, overexpression of USP7 has been detected in multiple myeloma, neuroblastoma, hepatocellular carcinoma, prostate cancer, breast cancer, and ovarian cancer, in which inhibition of USP7 suppresses proliferation and induces death of cancer cells independently of their p53 status."
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"USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin."
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"Hausp modulates proliferation by catalyzing the removal of polyubiquitin chains from the tumor suppressor p53 and from the p53 destabilizing E3 ligases Mdm2 and MdmX."
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"USP7 silencing in HL-60 cells (Supplementary Fig. 1A) significantly reduced cell proliferation (Fig. 1a) by increasing apoptotic cell death (Fig. 1b) and the proportion of cells in the G1 phase (Fig. 1c)."
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"Moreover, the knockdown of USP7 significantly suppressed the proliferation of JURKAT and MOLT-4 cells (Fig. 5d)."
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"Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo, accompanied by downregulation of the NOTCH1 protein level."
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
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"By overexpressing PLK1, USP7 that had been depleted by RNAi ceased to induce chromosome misalignment in mitosis and again supported cell proliferation and cell survival."
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"The result showed that cell proliferation was inhibited by the knockdown of nucleolin, HAUSP, and nucleolin and HAUSP double-knockdown, respectively (XREF_FIG)."
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"Both of USP7 and cyclin A2 synergistically promote the proliferation and metastasis of HCC cells, reducing intracellular DNA damage."
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"USP7 knockdown suppresses OSCC cell proliferation and induces cell apoptosis."
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"USP7 knockdown or its inhibitor suppressed cell proliferation and chondrogenic differentiation but improved hypertrophic differentiation."
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"Moreover , USP7 inactivates the ubiquitinated form of Lysine-specific demethylase 1 ( LSD1 ) and promotes cell proliferation through the suppression of cell cycle arrest in brain cancer cells [ 83 ] ."
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"Subsequently, using SKOV3 human ovarian adenocarcinoma cells, we showed that either USP7 or MARCH7 enhanced the proliferation and invasion abilities."
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"Knockdown of USP7 expression increases p53 expression and inhibits colon cancer cells proliferation (Colland et al., 2009)."
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"Our results show that suppression of USP7 activity via p5091 and siUSP7 caused a decrease in cell proliferation for both MCF7 and T47D cell lines regardless of their TP53 mutation status ."
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"USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non small cell lung cancer cells."
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"In this regard, we discovered that knockdown of USP7 blocked T-ALL cell proliferation in vitro and in vivo, and inhibition of USP7 resulted in T-ALL cell growth suppression and apoptosis."
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"In this context, we hypothesize that a possible dysregulation of USP7 may contribute to resistance in AML.In this study, we first showed that pharmacological or RNA interference-mediated inhibition of USP7 significantly reduced AML cell proliferation in vitro and in vivo, impaired replication fork progression and increased AML cell death."
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"Genetic knockdown or pharmacological inhibition (P5091 or P22027) of USP7 reduced the proliferation rate of lung cancer cells and decreased the capacity of colony formation of lung cancer cells invitro, whereas lung cancer cells growth inhibition by FTO knockdown is restored by overexertion of USP7."
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"Specific inhibitors of USP7 (P5091 and parthenolide) were shown to attenuate Wnt and beta-catenin-induced proliferation and migration and suppress tumor growth in HCT116 xenograft mouse models and are yet to be examined in clinical settings [XREF_BIBR, XREF_BIBR]."
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"USP7, another predicted TF in this study, was reported to promote proliferation, migration and invasion of HB cell lines through activation of PI3K/AKT signaling (Ye et al., 2021)."
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"These data suggested that USP7 knockdown inhibited HSC3 cell proliferation by regulating cell cycle and cyclin-dependent kinase inhibitors-related proteins, thus promoting HSC3 cells apoptosis by upregulating pro-apoptotic related protein."
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"In conclusion, USP7 modulates the proliferation and differentiation of ATDC5 cells via the Sox9-PTHrP-PTH1R axis."
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"Further experiments showed that down-regulation of USP7 could reduce cell proliferation , migration , and invasion ."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"Altogether, these results show that USP7 inhibition significantly reduces leukemic cells proliferation and impairs their viability in vitro and in vivo.We then performed similar experiments on primary AML cells and normal peripheral blood mononuclear cells (PBMC)."
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"The deubiquitylating enzyme USP7 was previously characterized as a tumor suppressor gene, but was recently proven to promote cell proliferation in NSCLC [XREF_BIBR, XREF_BIBR]."
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"USP7 silencing decreased proliferation, migration, and invasion rates of HCC cells."
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"In this paper, we demonstrate that inhibition of deubiquitinylase USP7 significantly reduces cell proliferation in vitro and in vivo, blocks DNA replication progression and increases cell death in AML."
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"Disruption of the USP7 function induces HCC cell death and inhibits cell proliferation and migration, which might be due to BCL2 associated X (BAX) activation."
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"Altogether, these results show that USP7 inhibition significantly reduces leukemic cells proliferation and impairs their viability in vitro and in vivo."
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