IndraLab

Statements

Phosphorylated CTNNB1 inhibits CTNNB1. 3 / 3
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"In colon cancer cells, lycopene suppressed Akt activation and non phosphorylated beta-catenin protein level, and augmented the phosphorylated form of beta-catenin, which were associated with reduced protein expression of cyclin D1."
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"Then, inhibition of beta-catenin phosphorylation raises the levels of beta-catenin in the cell and allows beta-catenin to enter the nuclei to bind to the transcription factor TCF/LEF, thereby initiating transcription of downstream target genes [XREF_BIBR]."
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"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."
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