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"We confirmed USP7 suppression of TRAF mediated innate immune signaling in an assay employing transfected, overexpressed mitochondrial antiviral signaling protein (MAVS), an effector of signaling initiated by retinoic acid inducible gene I (RIG-I)-like receptors and functioning through TRAFs, and a cotransfected IFN-beta-luciferase reporter (XREF_FIG)."