IndraLab

Statements

OTULIN inhibits Ubiquitin. 6 / 6
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"As expected, OTULIN treatment abolished the detection of ubiquitin chains (Fig XREF_FIG A, top panel), confirming that linear ubiquitination occurs in adult flies."
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"When the deubiquitinating enzymes A20, CYLD, and OTULIN degrade the ubiquitin chain of RIPK1, complex I dissociate, and the released RIPK1 forms the cytoplasmic death-induced signaling complex (DISC), Complex IIa, or complex IIb, inducing programmed cell death (7)."
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"The protease OTULIN, revealed by Dixit and colleagues to limit cell death and inflammation via ubiquitin (regulatory protein) modification (22), is another potential therapeutic target."
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"In this study, the ‘deubiquitinase’ OTULIN was shown to restrict bacterial growth by controlling the density of linear ubiquitin chains on the bacterial surface, which serves as a platform for NF-κB activation.Finally, lattice light-sheet microscopy (LLSM) is a newly developed super-resolution microscopy method, which capitalises on previous microscopy techniques (light-sheet microscopy, SIM) and provides gentle and fast super-resolution in a volumetric sample ."
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"OTULIN orients the linear diUb substrate with the amino terminus of the proximal Ub ( Figure 1 B) in the active site and prevents access by other Ub lysines, further enforcing specificity for linear U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTULIN prevents such promiscuity by requiring a properly positioned Ub residue, Glu16, for catalytic efficiency."
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