IndraLab

Statements

COPS5 activates Neoplasm Metastasis. 12 / 13
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"Taken together, the results indicate that CSN5 can contribute to PC invasion and metastasis through activation of FOXM1 and MMP2 axis."
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"Our previous studies showed that Jab1 and COPS5 was highly expressed in breast cancer and played an essential role in the breast cancer pathogenesis, and that Jab1 knockdown significantly inhibited breast cancer cell proliferation and metastasis."
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"Additionally , we found there was a positive correlation between CSN5 and angiopoietin-like protein 2 ( ANGPTL2 ) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2 ."
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"Further investigation revealed that CSN5 led to the metastasis and EMT activation of RCC cells through increasing ZEB1 expression."
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"Further, silencing of CSN5 expression markedly inhibited PC invasion and metastasis in vitro and in vivo, accompanied by decreased MMP2 expression."
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"CSN5 promotes renal cell carcinoma metastasis and EMT by inhibiting ZEB1 degradation."
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"Our previous studies showed that Jab1 / COPS5 was highly expressed in breast cancer and played an essential role in the breast cancer pathogenesis , and that Jab1 knockdown significantly inhibited breast cancer cell proliferation and metastasis ( 12 ) ."
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"Additionally, CSN5 contributes to the metastasis and EMT (epithelial-mesenchymal transition) of RCC cells."
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"CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization of FOXM1."
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"Previous studies have shown that CSN5 led to the metastasis and EMT activation of cancer cells through decreasing ZEB1 ubiquitination XREF_BIBR."
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"Moreover, the anti-metastasis role of CSN5 silence was reversed by MMP2 overexpression, whereas knockdown of MMP2 decreased PC metastasis driven by upregulation of CSN5."
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"Additionally, we found there was a positive correlation between CSN5 and angiopoietin like protein 2 (ANGPTL2) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2."
33508120