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COPS5 activates Neoplasm Metastasis. 25 / 26
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"Although we have verified that CSN5 is highly expressed and enhances metastasis in hepatocellular carcinoma, its precise role in metabolism was previously unclear."
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"Furthermore, we found that knockdown of CSN5 inhibited the metastasis abilities and EMT of RCC cells."
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"In renal cell carcinoma, CSN5 promotes EMT and metastasis through inhibition of ZEB1 degradation (14)."
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"In addition, CSN5, through stabilization of FOXM1, promotes invasion and metastasis in pancreatic cancer [ 28 ]."
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"Overall, these results demonstrate that CSN5 contributes to RCC cell's metastasis and EMT by increasing ZEB1 expression.As dysregulation of CSN5 upregulated or downregulated ZEB1 protein but not ZEB1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 2 D–F, the migration and invasion assay showed that knockdown of CSN5 significantly suppress metastasis of RCC cells in vitro ."
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"Blocking glycolysis by using 3-BrPA reversed the pro-metastatic effect of CSN5 overexpression ( Fig. 3 E–I), which further confirmed that CSN5 depends on glycolysis to promote metastasis."
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"In addition, CSN5 ectopic overexpression led to an increase of HK2 protein levels, glycolytic flux, and metastasis, but this situation was reversed if HK2 was suppressed by RNA interference (RNAi) or [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous studies have shown that CSN5 led to the metastasis and EMT activation of cancer cells through decreasing ZEB1 ubiquitination XREF_BIBR."
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"Further, we found that CSN5 enhances viability and metastasis of RCC cells by promoting the process of EMT."
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"Additionally, we found there was a positive correlation between CSN5 and angiopoietin like protein 2 (ANGPTL2) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2."
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"CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization of FOXM1."
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"In present study, our data indicated that knockdown of CSN5 could decrease the invasion and metastasis of HCC in vitro and in vivo ."
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"Moreover, the anti-metastasis role of CSN5 silence was reversed by MMP2 overexpression, whereas knockdown of MMP2 decreased PC metastasis driven by upregulation of CSN5."
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"CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization of FOXM1 [37]."
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"Our previous studies showed that Jab1 / COPS5 was highly expressed in breast cancer and played an essential role in the breast cancer pathogenesis , and that Jab1 knockdown significantly inhibited breast cancer cell proliferation and metastasis ( 12 ) ."
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"In hepatocellular carcinoma cells, COPS5 promotes metastasis via stabilizing hexokinase 2, which is a rate-limiting enzyme of glycolysis ( Huang et al., 2020 )."
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"Taken together, the results indicate that CSN5 can contribute to PC invasion and metastasis through activation of FOXM1 and MMP2 axis."
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"Additionally , we found there was a positive correlation between CSN5 and angiopoietin-like protein 2 ( ANGPTL2 ) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2 ."
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"Thus, we speculated as to whether CSN5 promoted HCC metastasis through HK2 and glycolysis."
31991125
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"Our previous studies showed that Jab1 and COPS5 was highly expressed in breast cancer and played an essential role in the breast cancer pathogenesis, and that Jab1 knockdown significantly inhibited breast cancer cell proliferation and metastasis."
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"Importantly, in order to verify that curcumin has an anti-HCC metastasis effect via inhibiting CSN5, we performed rescue experiments and found that curcumin attenuated the increase of HCC cell invasio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further, silencing of CSN5 expression markedly inhibited PC invasion and metastasis in vitro and in vivo, accompanied by decreased MMP2 expression."
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"CSN5 promotes HCC metastasis by upregulating glycolysis, which leads to immune escape and worse prognosis."
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"Moreover, our results demonstrated that CSN5 led to the metastasis and EMT activation of RCC cells through upregulation of ZEB1."
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