A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

BRAF binds KRAS and CRCs. 1 / 1
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"In CRC, the MSI phenotype is characterized by the accumulation of numerous mutations across the genome, mainly in microsatellite sequences, due to a defective mismatch repair system. xref Both MSI‐positive advanced CRCs and precursors of MSI‐H CRCs are closely associated with BRAF or KRAS mutations and high levels of genomic methylation (CIMP‐high). xref , xref However, whether the same theory can be applied to EGC, which has been shown to preferentially develop into hereditary nonpolyposis colorectal cancer (HNPCC), has not been proven."