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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRAF binds KRAS and CRCs. 1 / 1

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"In CRC, the MSI phenotype is characterized by the accumulation of numerous mutations across the genome, mainly in microsatellite sequences, due to a defective mismatch repair system. xref Both MSI‐positive advanced CRCs and precursors of MSI‐H CRCs are closely associated with BRAF or KRAS mutations and high levels of genomic methylation (CIMP‐high). xref , xref However, whether the same theory can be applied to EGC, which has been shown to preferentially develop into hereditary nonpolyposis colorectal cancer (HNPCC), has not been proven."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...