IndraLab

Statements

CDK1 phosphorylates NPM1 on T234. 10 / 10
1 3 3 1 | 2
phosphoelm
No evidence text available
14670079
hprd
No evidence text available
17287340
hprd
No evidence text available
11278991
hprd
No evidence text available
20068231
biopax:phosphositeplus
No evidence text available
signor
"Both subtypes of B23 proteins were phosphorylated during mitosis by cyclin B/cdc2. The RNA binding activity of B23.1 was repressed through cyclin B/cdc2-mediated phosphorylation at specific sites in B23. Thus, the RNA binding activity of B23.1 is stringently modulated by its phosphorylation and subtype association."
12058066
signor
"CDK1-cyclin B phosphorylates NPM/B23 on Thr234."
11278991
reach
"10 CDK1 phosphorylates NPM at the beginning of mitosis at Thr199 and Thr234/237, resulting in inhibition of NPM RNA binding activity."
25908633
reach
"CDK1 phosphorylation of NPM at threonine 234/237 is critical in HCC migration and invasion."
26536659
signor
"We have recently found that nucleophosmin (npm/b23), a phosphoprotein primarily found in nucleolus, associates with unduplicated centrosomes and is a direct substrate of cdk2-cyclin e in centrosome duplication."
14670079