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USP10 binds SIRT6. 27 / 31
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"Moreover, the specific interaction between the endogenous USP10 and SIRT6 was confirmed in HCT116 colon cancer cells because SIRT6 protein was detected in the immunoprecipitates with anti-USP10 antibody, but not with the control mouse IgG ( xref )."
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"We demonstrated the interaction between USP10 and Sirt6 in AB induced CH phenotype by USP10 knockout or transgenic mice, but no Sirt6 knockout or transgenic mice."
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"As indicated in XREF_FIG, USP10 interacts with SIRT6 but not with any of the other six sirtuin family proteins."
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"For example, in colon cancer, USP10 interacted with and stabilized SIRT6 through suppressing SIRT6 ubiquitination [25]."
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"USP10 interacts with SIRT6."
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"For example, in colon cancer, USP10 interacted with and stabilized SIRT6 through inhibiting SIRT6’s ubiquitination, suppressing proliferation [25]."
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"Collectively, these data demonstrate that USP10 can interact with Sirt6 and promote the ubiquitination of Sirt6 in cardiomyocytes and then inhibit the downstream Akt signaling pathway and cardiac hypertrophy."
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"We demonstrated the interaction between USP10 and Sirt6 in AB‐induced CH phenotype by USP10 knockout or transgenic mice, but no Sirt6 knockout or transgenic mice."
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No evidence text available
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"As indicated in xref , USP10 interacts with SIRT6 but not with any of the other six sirtuin family proteins."
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"Together with the fact that USP10 interacts with SIRT6, our studies indicate that USP10 is a specific deubiquitinase of SIRT6."
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"Next, we observed that USP10 interacted with Sirt6 in cardiomyocytes using endogenous co-IP experiments."
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"To test this hypothesis, we validated the specificities of USP10 and SIRT6 interactions."
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"Of note, our study demonstrated that USP10 can bind to Sirt6, leading to reduced alleviation of CH."
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"Conversely, SIRT6 specifically interacts with USP10 but not with USP22 or USP47 ( xref )."
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"To test this hypothesis, we validated the specificities of USP10 and SIRT6 interactions."
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"Furthermore, USP10 physically binds to sirtuin 6 (Sirt6) and Sirt6 mediates the effect of USP10 on the regulation of CH."
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"More interestingly, G3BP2, a previously known USP10 interacting protein, was detected in the SIRT6-pulldown products, suggesting that SIRT6 forms a complex with USP10 and G3BP2."
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"USP10 interacts with SIRT6."
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"Together with the fact that USP10 interacts with SIRT6, our studies indicate that USP10 is a specific deubiquitinase of SIRT6."
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"Of note, our study demonstrated that USP10 can bind to Sirt6, leading to reduced alleviation of CH."
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"Next, we observed that USP10 interacted with Sirt6 in cardiomyocytes using endogenous co‐IP experiments (Figure  xref and xref )."
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"Conversely, SIRT6 specifically interacts with USP10 but not with USP22 or USP47 (XREF_FIG)."
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"Moreover, the specific interaction between the endogenous USP10 and SIRT6 was confirmed in HCT116 colon cancer cells because SIRT6 protein was detected in the immunoprecipitates with anti-USP10 antibody, but not with the control mouse IgG (XREF_FIG)."
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"Mechanistically, we demonstrated that USP10 activation and interaction with Sirt6 in response to angiotensin II led to a marked increase in the ubiquitination of Sirt6 and resulted in Akt signaling downregulation and attenuation of cardiomyocyte hypertrophy."
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"Indeed, we detected the elevated promoter binding of SIRT6 in cells with USP10 over-expression ( xref )."
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"Collectively, these data demonstrate that USP10 can interact with Sirt6 and promote the ubiquitination of Sirt6 in cardiomyocytes and then inhibit the downstream Akt signaling pathway and cardiac hypertrophy."
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