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USP4 activates TNF-alpha-induced IkappaB-alpha. 1 / 1

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"Studies focused on the other USPs demonstrated that USP14 overexpression regulates IkappaB polyubiquitination to stimulate its degradation 26, and ectopic expression of USP4 inhibits the TRAF2- and TRAF6 stimulated NF-kappaB reporter gene and negatively regulates the TNF-alpha-induced IkappaB-alpha degradation and NF-kappaB activation 27."

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USP4 activates TNF-alpha-induced IkappaB-alpha. 1 / 1

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