IndraLab

Statements


MiR-181b decreases the amount of CYLD. 4 / 4
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"Specifically, upregulation and downregulation of miR-181b (through transfection of either pre- or small interfering miR-181b, respectively) could negatively regulate CYLD protein levels as well as N2A cell survival rate and apoptosis following CoCl 2 -induced injury."

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"However, western blot analysis showed that overexpression of miR-181b remarkably suppressed CYLD expression in SFCs and that inhibition of miR-181b increased CYLD expression in SFCs, indicating that miR-181b regulates CYLD in SFCs at the post-transcriptional level."

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"As was expected, miR-181b repressed CYLD expression by directly targeting its 3 ' UTR."

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"MiR-181b is directly regulated by NF-kappaB and inhibits CYLD expression, which in turn positively regulates NF-kappaB activity [14,26]."