IndraLab

Statements

IFNA activates USP18. 10 / 10
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"Here, goat IFN-α induced the upregulation of the negative regulatory factors SOCS1 and USP18, and the positive regulatory factors IFI6, cGAS, TLR3, and STAT1."
35632770
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"In our microarray analysis of IFN treated PHH, USP18 was induced preferentially by IFN-alpha."
22677194
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"IFNalpha induced beta cell apoptosis in USP18 silenced cells is mediated via three members of the BH3-only protein family."
23152055
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"Interestingly, unlike the results shown in XREF_FIG for ISG15, ISG56 and ISG12, we observed little or no IFN-alpha induction of the ISG43 mRNA by northern blotting in A. 2 Akata cells (which exhibited high and prolonged ISG expression), whereas induction of ISG43 expression was easily detectable in A. 15 cells (data not shown)."
19551150
reach
"Indeed, USP18 was induced almost exclusively by IFN-alpha."
22677194
sparser
"The defect in the UBP43-mediated negative feedback control of IFN signaling that we have uncovered is in the IFN-α-induced expression of UBP43, either in the transcriptional activation of the UBP43 gene by IFN-α, or in a co- or post-transcriptional event that results in a specific reduction in UBP43 mRNA production."
19551150
eidos
"Supporting this idea , we could verify that USP18 was expressed in both Tregs and Tconvs and was strongly induced by IFNalpha in a time - and dose-dependent fashion , as measured by intracellular staining of the USP18 protein ( not shown ) ."
33376595
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"Furthermore, knockdown of USP18 increases both ISG induction and anti-HCV activity of IFN-alpha, and data have shown that IFN-alpha treatment given to mice in vivo increases hepatic USP18 and blunts the effect of a subsequent dose of IFN-alpha."
27009955
reach
"In addition, we show that IFN-alpha upregulates ISG15 and USP18 via STAT1, and that, in turn, each of these 2 proteins alone can mimic the effects of IFN-alpha on neurogenesis."
29040650
eidos
"FIG 5 : IFN-alpha , LPS , and TNF-alpha do not induce type 1/2 IFN in primary murine hepatocytes but do induce USP18 ."
27009955