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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNH3 activates GCG. 2 / 2

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"We found that RNAi inhibition of unc-51, bec-1, vps-34, lgg-1, and atg-18 each significantly reduced the mean lifespan of glp-1 (e2141) animals (XREF_FIG and XREF_SUPPLEMENTARY), and we observed similar results with an additional germline deficient mutant, mes-1 (bn7) [XREF_BIBR] (XREF_SUPPLEMENTARY)."

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"In contrast, loss of BEC-1 function further decreased germ cell proliferation in the glp-1 (e2141lf) loss of function allele (XREF_SUPPLEMENTARY), which is characterized by a reduction in germline progenitors, and a severe Glp (Germline abnormal proliferation) phenotype, where germ cells do not proliferate and differentiate prematurely [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...