IndraLab

Statements

MAPK inhibits KCNMA1. 5 / 5
| 5
reach
"After demonstrating that inhibiting MAPK increased BK channel activity in HEK293T cells treated with dynasore, we tested whether inhibition of MAPK could also activate the BK channels in the split-open CCD of the rat kidney treated with the dynamin inhibitor."
23673010
reach
"Thus, inhibition of MAPK kinase increased BK channel activity in PC in the presence or in the absence of dynasore in the isolated CCD."
23673010
reach
"The stimulatory effect of MAPK on BK channels was PC specific because inhibition of MAPK failed to increase the BK channel numbers in IC."
23673010
reach
"However, the observation that inhibition of MAPK further increased the BK channel activity in the cells treated with dynasore suggests strongly that activation of the BK channels induced by inhibition of ERK and P38 MAPK was also the results of other than suppressing endocytosis."
23673010
reach
"Therefore, the results suggest that BK channel activity in PC may be constitutively suppressed by endogenous MAPK."
23673010