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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP6 activates CDA. 2 / 2

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"Using an enzyme-modified neutral comet assay after high-LET protons, we found that depletion of USP6 significantly reduces the efficiency of CDD repair (Fig. 4A [compare blue and yellow bars] and Fig. 4B), but not DSB repair, in comparison to NT control siRNA treated cells (Fig. 4A [compare green and red bars] and Fig. 4C)."

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"USP6 depletion caused cell cycle arrest and a deficiency in CDD repair mediated through instability of poly(ADP-ribose) polymerase-1 (PARP-1) protein."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...