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USP4 activates oncogene-induced primary cell transformation. 1 / 1

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"Indeed , it has been suggested that Usp4 is a potential oncogene because it inhibits p53 activity , p53-associated apoptosis and cell-cycle checkpoints ; depletion of USP4 promotes cell senescence ; loss of USP4 inhibits oncogene-induced primary cell transformation , and finally USP4 is over-expressed in a subset of human cancers [ 86 ] ."

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USP4 activates oncogene-induced primary cell transformation. 1 / 1

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