IndraLab

Statements

ITGAM increases the amount of TLR4. 4 / 4
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"As shown in XREF_FIG, there was no difference in the percentage of lung CD11b + DCs that expressed TLR4 or TLR5, or the mean fluorescence intensity (MFI) of TLR4 and TLR5 expression by lung CD11b + DCs, in DNA-PKcs fl/fl as compared to DNA-PKcs fl/fl; Cd11c-Cre mice."
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"Decreased expression of TLR4 was coincident with decreased expression of the microglial activation markers CD11b (48% in IBCP group; 39% in WBCP group) and CD14 (43%; 30%)(n = 4, ANOVA , P < 0.01, post hoc Dunnett testing)."
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"Thus, modified expression of TLR4 or TLR5 by lung CD11b + DCs does not appear to mediate impaired T cell priming to HDM in DNA-PKcs fl/fl; Cd11c-Cre mice."
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"To further test if TLR4 expressing skin-resident immune cells are involved in the hBD2 induced itch, we conditionally ablated TLR4 expression in the myeloid cell lineage by generating the LysM cre; Tlr4 f/f mice as we found that TLR4 was primarily expressed by CD11b + / CD11c - dermal macrophages besides a small percentage of dendritic cells and eosinophils (see XREF_SUPPLEMENTARY in this article 's Online Repository at www.jacionline.org)."
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